Research Guidance

Thiru’s Research Publications

1.Anandakumar A; Rajendran V; Thirugnanasambantham P; Balasubramaniam M.,Muralidaran.R.(1981)Identification of the Ingredients in Curna,Kvatha curna,Lehya and Rasayana-A Simple Microscopic Method,Ancient Science of Life,Vol-1(1),58-66

2.AnanadaKumar.A.,Rajendran.V.,Thirugnanasambantham.,Balasubramanian.M.,and Muralidharan.R.,1982,The Pharmacognosy of Nattu Atividayam-The Corms of Cryptocoryne Spiralis Fisch,Ancient Science of LifeVol-1(4),200-205.

3.Gossypin induced analgesia in mice.
Viswanathan S, Thirugnanasambantham P,Reddy M K and Kameswaran L. European J Pharmacology, 98,289-291 (1984). 2. Flavonoid induced delay in the small intestinal transit: Possible mechanism of action Viswanathan S, Thirugnanasambantham P,Bapna J S and Kameswaran L. Arch.Int.Pharmacodyn., 270,151-157 (1984).

3. Effect of certain indigenous preparations on experimentally induced gastric ulcer. Kannappa Reddy M, Thirugnanasambantham P, Viswanathan S and Kameswaran.L. Nagarjun, 28,15-17 (1984).

4. Analgesic activity of certain bio flavonoids.
Thirugnanasambantham P, Viswanathan S , Kannappa Reddy M ,Santa Ramachandran and Kameswaran L. Indian J.Pharm.Sci.47, 230-231 (1985).

5. Studies on possible tolerance and mechanism of Gossypin analgesia. Viswanathan S , Thirugnanasambantham P ,Ramaswamy S and Kameswaran L. Indian J.Exptl. BioL. 23, 525-526 (1985).

6. Effect of Leucas aspera on experimental inflammation and mast cell degranulation Kannappa Reddy M, Thirugnanasambantham P, Viswanathan S, Santa Ramachandran and Kameswaran L. Ancient Sci. of Life, 5(3), 168-171 (1986).

7. Effect of flavones and its hydroxy derivatives on small intestinal transit in mice. Thirugnanasambantham P, Viswanathan S, Krishnamoorty. V, Mythirayee C, Bapna J S, Santa Ramachandran and Kameswaran L. Medical Science Research. 16,341 (1988).

8. Involvement of calcium in flavonoid analgesia .
Thirugnanasambantham P, Viswanathan S , Ramaswamy S, Krishnamoorty V, Mythirayee C, Santa Ramachandran and Kameswaran L European J Pharmacology,152, 367-369 (1988).

9. Analgesic activity of certain flavone derivatives –a structure activity study. Thirugnanasambantham P, Viswanathan S, Mythirayee C, Krishnamoorty V , Santa Ramachandran and Kameswaran L J.Ethnopharmacology, 28,207-214 (1990).

10. Possible development of dependance of gossypin –role of gossypin on morphine dependence Viswanathan S , Ramaswamy S, Thirugnanasambantham P, Santa Ramachandran and Kameswaran L Indian J.Exptl. Biol. 28,1183-1184 (1990).

11. Anti inflammatory and mast cell protective effect o Ficus religiosa, Viswanathan S, Thirugnanasambantham P, Kannappa Reddy M,Narasimhan S and Anantha Subramanian G Ancient Science of Life, 10 (2),122-125(1990).

12. A pyridine alkaloid from Ceropegia juncea. Thirugnanasambantham P, Kulothungan C, Viswanathan S , Kameswaran L , Balakrishna K and Sukumar E Phytochemistry, 30 (7) 2449-2450 (1991).

13. Pharmacological investigations on Pristimera grahamii leaves Sukumar E ,Hamsaveni gopal R,Bhima Rao R,Kundu A B, Viswanthan S, Thirugnanasambantham P and Gopalakrishnan C Fitoterapia LXII-5,429-433 (1991).

14. Analgesic activity of certain flavones derivatives. A structure activity study . Thirugnanasambantham P, Viswanathan S, Ramaswamy S, , Krishnamoorty V, Mythirayee C and Kameswaran L. Clin. Exptl.Pharmacol. Physiol, 20,59-63 (1993)

15. Analgesic activity of Leucas aspera. Kannappa Reddy M, Viswanathan S, Thirugnanasambantham P and Kameswaran L. Fitoterapia, 64,151-154 (1993).

16. A study on the role of cholinergic and gamma amino butyric acid systems in the antinociceptive effect of gossypin. Viswanathan S, Thirugnanasambantham P, Ramaswamy S and Bapna J S. Clin. Exptl.Pharmacol. Physiol, 20,193-196 (1993)

17. Anti inflammatory activity of flavone and its methoxy derivatives-A structure activity study. Muthaiah N S, Viswanathan S, Thirugnanasambantham P, Kannappa Reddy M and Vijayasekaran V Indian J. Phram. Sci. 55(5) ,180-183 (1993).

18. Effect of Leucas aspera on snake venom poisoning in mice and its possible mechanism of action. Kannappa Reddy M, Viswanathan S, Thirugnanasambantham P and Kameswaran L. Fitoterapia 64(5),442-446(1993).

19. Pharmacological actions of cerpegin, a novel pyridine alkaloid from ceropegia juncea. Sukumar E ,Hamsaveni gopal R,Bhima Rao R, Viswanathan S, Thirugnanasambantham P and Vijayasekaran V Fitoterapia, 66(5),403-406 (1995).

20. Pharmacological screening of ochana obtusata. Sivaprakasam P, Viswanathan S, Thirugnanasambantham P, Kannappa Reddy M and Vijayasekaran V Fitoterapia, 67,117-120.(1996).

21. Anti inflammatory activity of flavone and its hydroxy derivatives-A structure activity study. ArivudaiNambi R, Viswanathan S, Thirugnanasambantham P, Kannappa Reddy M, Dewan M l,Sijhir J J, Gopalakrishnan C and Vijayasekaran V. Indian J.Pharm.Sci. 58(1),18-21 (1996).

22. Prezwalskinone- B from the stem bark of ochna obtusata Sivaprakasam P, Viswanathan S, Thirugnanasambantham P, Vijayasekaran V , Sukumar E,Balakrishna K and Kundu A B. J. Indian Chem. Soc 74,165 (1997).

23. Antinociceptive , antiinlammatory and antipyreticeffects of ethanol extract of clerodendron serratum roots in experimental animals. Narayanan N, Thirugnanasambantham P, Viswanthan S, ,Vijayasekaran V and Sukumar E. J .Ethnopharmacology, 65.237-241 (1999)

24. Antipyretic, antinociceptive and anti inflammatory activity of Permna herbacea roots. Narayanan N, Thirugnanasambantham P, Viswanthan S, Kannappa Reddy M, Vijayasekaran V and Sukumar E Fitoterapia, 71 , 147-153 (2000).

25. Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. Rajendran N N, Thirugnanasambantham P, Viswanthan S,Parvathavarthini S and Ramaswamy S Indian J.Exptl Biol, 38, 182-185 (2000).

26. Modulation of insulin rather than the blood glucose of the pain threshold in acute physiological and flavones induced antinociception in mice. Rajendran N.N, Thirugnanasambantham P, Parvathavarthini S , Viswanathan S and Ramaswamy S Indian J.Exptl BioL 39 , 1009-1016,(2001).

27. Development and evaluation of andrographolide(from Andrographis paniculata) rectal suppositories. Senthilkumaran K, Thirugnanasambantham P, Viswanathan S and Sree Ramamurthy M Indian Drugs 39,648-650, (2002).

28. Pharmacognostical studies on the roots of clerodendron serratum. Narayanan N. Thirugnanasambantham P, Viswanathan S Pharmaceutical biology.40, 362-368 (2002)

29. An HPLC method for the estimation of andrographolide in rabbit serum. Senthilkumaran K, Thirugnanasambantham P, Viswanathan S and Sree Ramamurthy M Indian J.pharmacol. 35, 109-111,(2003).

30.Comparative anti bacterial activities of Clerodendron serratum and Premna herbacea roots. Narayanan N, Thirugnanasambantham P, Viswanthan S, Rajarajan S and Sukumar E. Indian J.Pharm.Sciences -66 453-454 (2004)

31. Effect of arogh, a herbal tea on elevated lipid profile in rats. Ganesh R,C, Thirugnanasambantham P, Mayiswaran E and Anoop Austin International Journal of Tropical Medicine, 2006 ,1(1) 18-22.

32 .Effect of polyherbal formulation (Diarun plus) on Streptozotocin induced experimental diabetes.
Senthilvel G,Jagadeesan M,Anoopaustin , Thirugnanasambantham P,Mayiswaran E,Balasubramanian M,Narayanan N, Viswanathan S. International Journal of Tropical Medicine, 2006,1(2),88-92

33. Efect of polyherbal formulation (Diarun plus)on the glycemic status modified by physiological means in non-diabetic mice and rats Senthilvel G, Jagadeesan M, Anoopaustin , Thirugnanasambantham P, Mayiswaran E, Balasubramanian M, Narayanan N, Viswanathan S. International Journal of pharmacology 2007,3(2),175-178

34. Anoop Austin, Senthilvel, G., Thirugnanasambantham, P., Balasubramanian, M. and Mayisvren, E., 2004. Clinical efficacy of Masthura in the treatment of male sub fertility, The Antiseptic, 101 (2) : 59-61.

35. Anoop Austin, Senthilvel, G., Thirugnanasambantham, P., Balasubramanian, M. and Mayisvren, E., 2004. Efficacy of Anxino in Rheumatoid Arthritis: A double blind, placebo-controlled, crossover study, Amala Research Bulletin 24: 52-56.

36. Senthilvel, G., Jegadeesan, M., Anoop Austin, Thirugnanasambantham, P., Balasubramanian, M. and Mayisvren, E., 2004. Evaluation of efficacy and tolerability of a herbal formulation (Diarun Plus) in the management of Type 2 Diabetes mellitus in Indian patients, Amala Research Bulletin 24 : 57-62.

37. Anoop Austin, Senthilvel, G., Thirugnanasambantham, P., and Mayisvren, E., 2005. Jeerna, a polyherbal formulation in treating Indian patients with PUD - A randomized clinical study, Amala Research Bulletin, 25 : 73-80.

38. Winford Rollands, Senthilvel, G., Anoop Austin, Thirugnanasambantham, P. and Mayisvren, E., 2006. Clinical report on Diarun plus in controlling elevated blood sugar level, The Antiseptic, 103 (6) : 348 – 349.

39. Senthilvel, G., Else Domnic, C.S., Kalyanasundaram, S., Thirugnanasambantham, P., Balasubramanian, M. and Anoop Austin, 2006. Randomized clinical trial on osteoarthosis, an holistic approach, The Antiseptic, 103 (10) : 591-593.

40. Kasthuri K.T., Radha R., Jayshree, N., Anoop Austin, and Thirugnanasambantham, P., 2010. Standardization and In Vitro Anti Inflammatory Studies of A Poly Herbal Oil Formulation – Megni, Research Journal of Pharmacy and Technology, 3 (3) : 792 – 794. http://rjptonline.org/RJPT/RJPT_3_3_2010_Abstract.pdf

41. Ganesh, R., Viswanathan, S., Thirugnanasambantham, P., Mayisvren, E., and Anoop Austin, 2006. A study on the effect of a herbal tea (Arogh) on elevated lipid profile in rats, International Journal of Tropical Medicine, 1 (1) : 18-22. http://docsdrive.com/pdfs/medwelljournals/ijtmed/2006/18-22.pdf

42. Senthilvel, G., Anoop Austin, Thirugnanasambantham, P., Mayisvren, E., Balasubramanian, M. and Jegadeesan, M., 2006. Effect of a polyherbal formulation (Diarun plus) on streptozotocin induced diabetes in rats and mice, International Journal of Tropical Medicine, 1 (2) : 88-92. http://www.medwelljournals.com/abstract/?doi=ijtmed.2006.88.92

43. Anoop Austin, Senthilvel, G., Thirugnanasambantham, P. and Mayisvren, E., 2006. Clinical efficacy of a Polyherbal Instant Formulation (Arogh) in the management of Hyperlipidaemia, The Cardiology, 2 (2) : 36-38. http://www.medwelljournals.com/abstract/?doi=tcard.2006.36.38

44. Senthilvel, G., Anoop Austin, Jegadeesan, M., Thirugnanasambantham, P., Mayisvren, E., Balasubramanian, M. and Viswanathan, S., 2007. Effect of a polyherbal formulation (Diarun plus) on the glycemic status modified by physiological means in non-diabetic mice and rats, International Journal of Pharmacology, 3 (2) : 175-178. http://198.170.104.138/ijp/2007/175-178.pdf

45. Senthilvel, G., Anoop Austin, Jegadeesan, M., Thirugnanasambantham, P., Mayisvren, E., Balasubramanian, M. and Viswanathan, S., 2007. Effect of a polyherbal formulation (Diarun plus) on the glycemic status modified by physiological means in non-diabetic mice and rats, Oriental Pharmacy and Experimental Medicine, 7 (2) : 128-132. http://www.opem.org/

46. Balaraman, R., Mohan, M., Aurangabadkar, V.M., Jadhav, G.B., Anoop Austin, Thirugnanasambathan, P., 2007. Effect of a polyherbal formulation on anxiety and behaviour mediated via monoamine neurotransmitters, Oriental Pharmacy and Experimental Medicine, 7 (4) : 409 – 417. http://www.opem.org/

47. Mohan, M., Gulecha, V.S., Aurangabadkar, V.M., Balaraman, R., Austin, A. and Thirugnanasambantham, P., 2009. Analgesic and anti-inflammatory activity of a polyherbal formulation (PHF – Arogh), Oriental Pharmacy and Experimental Medicine, 9 (3) : 232 – 237. http://www.opem.org/board_pds/files/9(3)-05(2874).pdf

47. Mohan, M., Gulecha, V.S., Aurangabadkar, V.M., Balaraman, R., Austin, A. and Thirugnanasambantham, P., 2009. Analgesic and anti-inflammatory activity of a polyherbal formulation (PHF – Arogh), Oriental Pharmacy and Experimental Medicine, 9 (3) : 232 – 237. http://www.opem.org/board_pds/files/9(3)-05(2874).pdf

List of Research Publications presented in Conference

1. Ganesh, R., Narayanan, N., Thirugnanasambantham, P., Viswanathan, S. and Parvathavarthini, S., 2000. Effect of Arogh on Hyperlipidemia, Drugs in the New Millennium, A multi disciplinary clinical symposium, at Southern Regional Conference of the Indian Pharmacological Society, Bangalore.

2. Srinivasan, P., Mayisvren, E., Thirugnanasambantham, P. and Shyamala Devi, C.S., 2002. Role of Liverem, a polyherbal formulation of enzymic antioxidant status in carbon tetra chloride induced hepatotoxicity, International Conference on Natural Antioxidants and free Radicals in Human health Radiation Biology, Bombay.

3. Anbarasi, K., Thirugnanasambantham, P., Mayisvren, E. and Shyamala Devi, C.S., 2003. Protective effect of Vilva, a polyherbal formulation in rats exposed to cigarette smoke, International Conference on the role of Indian Systems of Medicine in the 21st Century.

4. Suchalatha, S., Thirugnanasambandam, P., Maheswaran, E. and Shyamala Devi, C.S., 2004. Role of Arogh, a polyherbal formulation to mitigate oxidative stress in experimental myocardial infarction, Indian Journal of Experimental Biology, 42 (2) : 224-226. http://www.niscair.res.in/sciencecommunication/ResearchJournals/rejour/ijeb/ijeb2k4/ijeb_feb04.asp

Books

1. Anoop Austin and Thirugnanasambantham, P., 2011. Evidence based therapy on “Arogh”, a herbal tea formulation - A review, Eds. Natural Products and their Active Compounds on Disease Prevention, Food Science and Technology, NOVA Publishers INC., New York